Diagnostic dilemma: Huge mass in woman's stomach was likely caused by Ozempic-style drug — and dissolved with diet soda

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The patient: A 63-year-old woman in Massachusetts

The symptoms: The patient went to the emergency department after experiencing nausea and vomiting for about a month, along with decreased appetite. She told doctors that she'd also experienced a burning pain in her upper abdomen and right side of her torso, which wrapped around to her back. She'd tried treating these symptoms with two common over-the-counter medications for acid reflux, but the treatments didn't help.

In the year prior, the patient had started taking semaglutide, a type of drug known as a GLP-1 receptor agonist — the same class of drug as Ozempic. These injected drugs are used to treat type 2 diabetes and assist in chronic weight management; in this case, the woman had a history of type 2 diabetes and obesity. Since starting the medication, she'd lost about 40 pounds (18 kilograms), but notably, that weight loss had accelerated over the previous month, she noted.

What happened next: Doctors took a CT scan of the patient's abdomen an...

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