Scientists identify rare genetic mutation that dramatically raises risk of lung cancer in nonsmokers

Scientists have identified an inherited genetic mutation that greatly increases the risk of lung cancer, even in people who have never smoked.

The mutation involves the EGFR gene, which helps control cells' growth, division and survival. People who had never smoked and who had the genetic mutation — called EGFR T790M — were 62 times more likely to develop lung cancer than nonsmokers without the mutation, according to the new study, published Thursday (Sept. 17) in the journal Science.

By comparison, people who smoked but didn't carry the mutation were four times likelier to develop lung cancer than nonsmokers, so the mutation alone carried a higher risk of the disease.

Among people in the study who smoked and carried the mutation, T790M increased their cancer risk 11-fold compared with other smokers.

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